A thriller that tells the story of Dr. Ephraim Goodweather, the head of the Center for Disease Control Canary Team in New York City. He and his team are called upon to investigate a mysterious viral outbreak with hallmarks of an ancient and evil strain of vampirism. As the strain spreads, Eph, his team, and an assembly of everyday New Yorkers, wage war for the fate of humanity itself.

Two female vampires in modern-day New York City are faced with daunting romantic possibilities.

The vampire Angelus, now known as Angel, has a human soul, but committed terrible crimes in the past. Seeking forgiveness and trying to redeem himself, he moves from Sunnydale (and a relationship with Buffy Summers, of "Buffy the Vampire Slayer") to Los Angeles, where he helps the downtrodden by thwarting the supernatural creatures that prey on them.

Moronic American student Rusty arranges a student exchange program for his closest friend and him to study in Romania for six months and meet his Internet girlfriend Draguta. He travels with potheads Pete and Wang; Pete's girlfriend Lia and his twin sister Danni; the naive and romantic Newmar and his dippy girlfriend Lynne; the nerd Brady and crook Cliff. His friends actually intend to party. While traveling by train to Razvan, they learn that five hundred years ago, vampire Radu lost his beloved Stephania, whose spirit was trapped in a music box. Radu has kept Stephania's body and has been seeking the music box to bring Stephania back. Meanwhile, one of Radu's minions retrieves the music box but is mortally wounded by the vampire slayer Teodora Van Sloan and he drops the object in a gypsy's basket. Newmar buys the music box and gives it to Lynne. When they arrive at the university...

In Mexico, another vampire slayer, Derek Bliss, is hired by a shady priest and aided by a group of fellow slayers in finding a large nest of 'suckers' and their powerful leader, a vampire princess. She is seeking a legendary black crucifix - the same crucifix used unsuccessfully in the first movie to perform a ritual which will enable vampires to walk in sunlight and be invulnerable.